The Missing LINC for Genetic Cardiovascular Disease?

The Missing LINC for Genetic Cardiovascular Disease?

As of 2014, cardiovascular disease (CVD) was listed as the underlying cause for 1 of every 3 deaths in the United States. Many forms of CVD have a strong genetic component, and the number of causal genes elucidated greatly depends on the type of CVD under study. Understanding the molecular basis of CVD can guide medical decisions of the practitioner, patient, and family members. Currently, gene...

Build a braveheart: the missing linc (RNA).

Noncoding RNAs: The Missing “Linc” in p53-Mediated Repression

The tumor suppressor protein p53 coordinates the cellular response to stress through regulation of gene expression. Now, Huarte et al. (2010) identify a long intergenic noncoding RNA as a new player in p53-mediated repression of genes involved in apoptosis.

The LINC complex and human disease.

The LINC (linker of nucleoskeleton and cytoskeleton) complex is a proposed mechanical link tethering the nucleo- and cyto-skeleton via the NE (nuclear envelope). The LINC components emerin, lamin A/C, SUN1, SUN2, nesprin-1 and nesprin-2 interact with each other at the NE and also with other binding partners including actin filaments and B-type lamins. Besides the mechanostructural functions, th...

Vitamin D deficiency and cardiovascular disease: the missing link

ciated primarily with bone health, and typically, a marked deficiency causes rickets in children and osteomalacia in adults. There is a well-described association between vitamin D deficiency and muscle weakness and skeletal pain [1,2]. However, the vitamin D receptor (VDR) is expressed not only in bone but also ubiquitously in other tissues and cells, including lymphocytes, cardiomyocytes, the...